Avagacestat | Tocris Bioscience 6363 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Avagacestat

catalog :

6363

quantity :

25 mg

price :

278 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6363

SKU :

6363/25

product name :

Avagacestat

description :

Highly potent -secretase inhibitor; orally bioavailable

target :

Secretase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

520.89

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent -secretase inhibitor (A 40 IC50 = 0.3 nM). Exhibits 137-fold selectivity for amyloid- precursor protein (APP) processing over Notch. Reduces plasma and brain A 40 and A 42 levels in vivo . Orally bioavailable.

catalog number base :

6363

product keywords :

gamma secretase inhibitors inhibits Abeta AB A 40 42 amyloid- precursor protein APP processing highly potent BMS-708163 Gamma-Secretase Amyloid Beta Peptides 6363,

extended description :

Highly potent -secretase inhibitor; orally bioavailable

chemical name text :

(2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

formula :

C 20 H 17 ClF 4 N 4 O 4 S

formula text :

C20H17ClF4N4O4S

cas num :

1146699-66-2

2020 USD :

269

2021 USD :

278 USD

alt names :

BMS-708163

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage