6363/5 | Tocris Bioscience 6363/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6363/5

catalog :

6363/5

quantity :

5 mg (also 25 mg)

price :

81 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fritsch J, Frankenheim J, Marischen L, Vadasz T, Troeger A, Rose John S, et al. Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells. Cells. 2021;10: pubmed publisher

image

image 1 :

Cat.No. 6363 - Avagacestat C20H17ClF4N4O4S CAS No. 1146699-66-2

product information

master code :

6363

SKU :

6363/5

product name :

Avagacestat

unit size :

5 mg (also 25 mg)

description :

Highly potent -secretase inhibitor; orally bioavailable

target :

Secretase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

520.89

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Avagacestat is a highly potent -secretase inhibitor (A 40 IC50 = 0.3 nM). Exhibits 137-fold selectivity for amyloid- precursor protein (APP) processing over Notch. Reduces plasma and brain A 40 and A 42 levels in vivo . Orally bioavailable.

top caption :

Highly potent -secretase inhibitor; orally bioavailable

extended description :

Highly potent -secretase inhibitor; orally bioavailable

chemical name text :

(2R)-2-[[(4-Chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoropentanamide

formula :

C20H17ClF4N4O4S

formula text :

C20H17ClF4N4O4S

cas num :

1146699-66-2

USD :

81 USD

product details :

Highly potent -secretase inhibitor; orally bioavailable

alt names :

BMS-708163

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage