VU 0650991 | Tocris Bioscience 6355 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VU 0650991

catalog :

6355

quantity :

10 mg (also 50 mg)

price :

224 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6355

SKU :

6355/10

product name :

VU 0650991

description :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

target :

Glucagon-Like Peptide 1 Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

440.73

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 M). Displays 40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro . Decreases blood insulin and increases blood glucose levels in vivo . Brain penetrant and orally bioavailable.

catalog number base :

6355

product keywords :

VU0650991 GLP1 glucagon like peptide 1 receptor antagonism antagonists brain penetrant orally bioavailable Glucagon-Like Peptide 1 Receptors 6355,

extended description :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

chemical name text :

7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

formula :

C 16 H 11 ClF 6 N 4 O 2

formula text :

C16H11ClF6N4O2

cas num :

488097-06-9

2020 USD :

215

2021 USD :

224 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage