6355/10 | Tocris Bioscience 6355/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6355/10

catalog :

6355/10

quantity :

10 mg (also 50 mg)

price :

282 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6355 - VU 0650991 C16H11ClF6N4O2 CAS No. 488097-06-9

product information

master code :

6355

SKU :

6355/10

product name :

VU 0650991

unit size :

10 mg (also 50 mg)

description :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

target :

Glucagon-Like Peptide 1 Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

440.73

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VU 0650991 is a noncompetitive glucagon-like peptide-1 (GLP-1) receptor antagonist (IC50 = 0.65 - 0.69 M). Displays 40-fold selectivity for GLP-1 receptor over glucagon receptors. Blocks activity of Exendin-4 (Cat. No. 1933) in potentiating insulin secretion from primary mouse pancreatic islets in vitro . Decreases blood insulin and increases blood glucose levels in vivo . Brain penetrant and orally bioavailable.

top caption :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

extended description :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

chemical name text :

7-(4-Chlorophenyl)-5,8-dihydro-1,3-dimethyl-5,5-bis(trifluoromethyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione

formula :

C16H11ClF6N4O2

formula text :

C16H11ClF6N4O2

cas num :

488097-06-9

USD :

282 USD

product details :

Non-competitive GLP-1 antagonist; orally bioavailable and brain penetrant

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage