6348/5 | Tocris Bioscience 6348/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6348/5

catalog :

6348/5

quantity :

5 mg

price :

96 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Moskal N, Visanji N, Gorbenko O, Narasimhan V, Tyrrell H, Nash J, et al. An AI-guided screen identifies probucol as an enhancer of mitophagy through modulation of lipid droplets. PLoS Biol. 2023;21:e3001977 pubmed publisher
P xe9 rez Mart xed A, Ramakrishnan S, Li J, Dugourd A, Molenaar M, De La Motte L, et al. Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes. elife. 2022;11: pubmed publisher
Xu C, Fu Y, Liu S, Trittipo J, Lu X, Qi R, et al. BATF Regulates T Regulatory Cell Functional Specification and Fitness of Triglyceride Metabolism in Restraining Allergic Responses. J Immunol. 2021;206:2088-2100 pubmed publisher
Chen G, Zhou G, Lotvola A, Granneman J, Wang J. ABHD5 suppresses cancer cell anabolism through lipolysis-dependent activation of the AMPK/mTORC1 pathway. J Biol Chem. 2021;296:100104 pubmed publisher

product information

master code :

6348

SKU :

6348/5

product name :

PF 06424439

unit size :

5 mg

description :

Potent and selective DGAT2 inhibitor

target :

Diacylglycerol O-Acyltransferase (DGAT) Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

536.05

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 06424439 is a potent and selective DGAT2 inhibitor (IC50 = 14 nM). Exhibits no significant activity at MGAT1-3 or DGAT1. Reduces triglyderide synthesis in human hepatocytes in vitro . Reduces plasma triglyceride and cholesterol levels in a rat dyslipidemia model. Orally bioavailable.

top caption :

Potent and selective DGAT2 inhibitor

extended description :

Potent and selective DGAT2 inhibitor

chemical name text :

[(3R)-1-[2-[1-(4-Chloro-1H-pyrazol-1-yl)cyclopropyl]-3H-imidazo[4,5-b]pyridin-5-yl]-3-piperidinyl]-1-pyrrolidinylmethanone methanesulfonate

formula :

C22H26ClN7O.CH4O3S

formula text :

C22H26ClN7O.CH4O3S

cas num :

1469284-79-4

USD :

96 USD

product details :

Potent and selective DGAT2 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage