AZ 5704 | Tocris Bioscience 6330 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 5704

catalog :

6330

quantity :

25 mg

price :

485 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6330

SKU :

6330/25

product name :

AZ 5704

description :

Potent and selective ATM kinase inhibitor; orally bioavailable

target :

ATM and ATR Kinase Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

434.47

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective ATM kinase inhibitor (IC50 = 0.6 nM in an enzyme inhibition assay). Exhibits > 600-fold selectivity for ATM over other kinases. Inhibits ATM kinase in an in vitro cellular assay (IC50 = 0.33 M). Potentiates the antitumor effects of the topoisomerase 1 inhibitor irinotecan (CPT 11, Cat. No. 2688) in tumor bearing, immunocompromised mice. Orally bioavailable.

catalog number base :

6330

product keywords :

AZ5704 orally bioavailable potent selective ATM kinase inhibitors ataxia telangiectasia mutated ATM & ATR Kinase Checkpoint Control Kinases 6330,

extended description :

Potent and selective ATM kinase inhibitor; orally bioavailable

chemical name text :

7-Fluoro-6-[6-(methoxymethyl)-3-pyridinyl]-4-[[(1S)-1-(1-methyl-1H-pyrazol-3-yl)ethyl]amino]-3-quinolinecarboxamide

formula :

C 23 H 23 FN 6 O 2

formula text :

C23H23FN6O2

cas num :

1941214-06-7

2020 USD :

475

2021 USD :

485 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage