Clozapine N-oxide dihydrochloride | Tocris Bioscience 6329 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Clozapine N-oxide dihydrochloride

catalog :

6329

quantity :

10 mg (also 50 mg)

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Torre Muruzabal T, Devoght J, Van den Haute C, Brône B, Van der Perren A, Baekelandt V. Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease. Acta Neuropathol Commun. 2019;7:160 pubmed publisher
Chang C, Gean P. The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice. Cell Rep. 2019;28:1195-1205.e3 pubmed publisher
Fernandez L, Vantomme G, Osorio Forero A, Cardis R, Beard E, Lüthi A. Thalamic reticular control of local sleep in mouse sensory cortex. elife. 2018;7: pubmed publisher
Khodai T, Nunn N, Worth A, Feetham C, Belle M, Piggins H, et al. PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia. Front Endocrinol (Lausanne). 2018;9:632 pubmed publisher

product information

brand :

Tocris

master code :

6329

SKU :

6329/10

product name :

Clozapine N-oxide dihydrochloride

description :

Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)

target :

DREADD Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

415.74

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Water soluble salt of Clozapine N -oxide (Cat. No.4936). Activator of muscarinic DREADDs. Exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.

catalog number base :

6329

product keywords :

Clozapine N-oxide 2HCl metabolite DREADDs Ligands muscarnic designer receptors CNO water soluble chemogenetics CNO (water-soluble) DREADDs Multidrug Transporters Non-selective Muscarinics 6329, Chemogenetics

extended description :

Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)

chemical name text :

8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride

formula :

C 18 H 19 ClN 4 O.2HCl

formula text :

C18H19ClN4O.2HCl

cas num :

2250025-93-3

2020 USD :

121

2021 USD :

126 USD

alt names :

CNO (water-soluble)

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage