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company name :
Tocris Bioscience
product type :
chemical
product name :
6329/10
catalog :
6329/10
quantity :
10 mg (also 50 mg)
price :
162 USD
more info or order :
citations: 21
Reference
Bariselli S, Mateo Y, Reuveni N, Lovinger D. Gestational ethanol exposure impairs motor skills in female mice through dysregulated striatal dopamine and acetylcholine function. Neuropsychopharmacology. 2023;48:1808-1820 pubmed publisher
Traut J, Mengual J, Meijer E, McKillop L, Alfonsa H, Hoerder Suabedissen A, et al. Effects of clozapine-N-oxide and compound 21 on sleep in laboratory mice. elife. 2023;12: pubmed publisher
Korchynska S, Rebernik P, Pende M, Boi L, Alp xe1 r A, Tasan R, et al. A hypothalamic dopamine locus for psychostimulant-induced hyperlocomotion in mice. Nat Commun. 2022;13:5944 pubmed publisher
Silva M, Decoster L, Trova S, Mimouni N, Delli V, Chachlaki K, et al. Female sexual behavior is disrupted in a preclinical mouse model of PCOS via an attenuated hypothalamic nitric oxide pathway. Proc Natl Acad Sci U S A. 2022;119:e2203503119 pubmed publisher
Yadav N, Noble C, Niemeyer J, Terceros A, VICTOR J, Liston C, et al. Prefrontal feature representations drive memory recall. Nature. 2022;608:153-160 pubmed publisher
Zhang C, Vincelette L, Reimann F, Liberles S. A brainstem circuit for nausea suppression. Cell Rep. 2022;39:110953 pubmed publisher
Császár E, Lénárt N, Cserép C, Kornyei Z, Fekete R, Pósfai B, et al. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. J Exp Med. 2022;219: pubmed publisher
Melkumyan M, Snyder A, Bingaman S, Arnold A, Silberman Y. Astrocytes play a critical role in mediating the effect of acute ethanol on central amygdala glutamatergic transmission. Neuropharmacology. 2021;205:108918 pubmed publisher
Zhang C, Koukouli F, Allegra M, Ortiz C, Kao H, Maskos U, et al. Inhibitory control of synaptic signals preceding locomotion in mouse frontal cortex. Cell Rep. 2021;37:110035 pubmed publisher
Lee E, Park J, Kwon H, Han P. Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice. Nat Commun. 2021;12:6682 pubmed publisher
De Filippo R, Rost B, Stumpf A, Cooper C, Tukker J, Harms C, et al. Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex. elife. 2021;10: pubmed publisher
Tan T, Wang W, Liu T, Zhong P, Conrow Graham M, Tian X, et al. Neural circuits and activity dynamics underlying sex-specific effects of chronic social isolation stress. Cell Rep. 2021;34:108874 pubmed publisher
Boender A, Bontempi L, Nava L, Pelloux Y, Tonini R. Striatal Astrocytes Shape Behavioral Flexibility via Regulation of the Glutamate Transporter EAAT2. Biol Psychiatry. 2020;: pubmed publisher
Unger E, Keller J, Altermatt M, Liang R, Matsui A, Dong C, et al. Directed Evolution of a Selective and Sensitive Serotonin Sensor via Machine Learning. Cell. 2020;183:1986-2002.e26 pubmed publisher
Smith A, Ogunseye K, DeBenedictis J, Peris J, Kasper J, Hommel J. Glutamatergic projections from homeostatic to hedonic brain nuclei regulate intake of highly palatable food. Sci Rep. 2020;10:22093 pubmed publisher
Zhang C, Kaye J, Cai Z, Wang Y, Prescott S, Liberles S. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021;109:461-472.e5 pubmed publisher
Sheahan T, Warwick C, Fanien L, Ross S. The Neurokinin-1 Receptor is Expressed with Gastrin-Releasing Peptide Receptor in Spinal Interneurons and Modulates Itch. J Neurosci. 2020;40:8816-8830 pubmed publisher
Torre Muruzabal T, Devoght J, Van den Haute C, Brône B, Van der Perren A, Baekelandt V. Chronic nigral neuromodulation aggravates behavioral deficits and synaptic changes in an α-synuclein based rat model for Parkinson's disease. Acta Neuropathol Commun. 2019;7:160 pubmed publisher
Chang C, Gean P. The Ventral Hippocampus Controls Stress-Provoked Impulsive Aggression through the Ventromedial Hypothalamus in Post-Weaning Social Isolation Mice. Cell Rep. 2019;28:1195-1205.e3 pubmed publisher
Fernandez L, Vantomme G, Osorio Forero A, Cardis R, Beard E, Lüthi A. Thalamic reticular control of local sleep in mouse sensory cortex. elife. 2018;7: pubmed publisher
Khodai T, Nunn N, Worth A, Feetham C, Belle M, Piggins H, et al. PACAP Neurons in the Ventromedial Hypothalamic Nucleus Are Glucose Inhibited and Their Selective Activation Induces Hyperglycaemia. Front Endocrinol (Lausanne). 2018;9:632 pubmed publisher
product information
master code :
6329
SKU :
6329/10
product name :
Clozapine N-oxide dihydrochloride
unit size :
10 mg (also 50 mg)
description :
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
target :
DREADD Activators
category :
Small Molecules
purity :
99%
observed molecular weight :
415.74
url print :
?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Clozapine N -oxide dihydrochloride is a water-soluble salt of Clozapine N -oxide (Cat. No.4936). Activator of muscarinic DREADDs. Clozapine N-oxide dihydrochloride exhibits improved bioavailability (6 - 7-fold higher plasma concentration) compared with CNO, with less conversion to clozapine in animal studies.
top caption :
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
extended description :
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
chemical name text :
8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine dihydrochloride
formula :
C18H19ClN4O.2HCl
formula text :
C18H19ClN4O.2HCl
cas num :
2250025-93-3
USD :
162 USD
product details :
Activator of hM3Dq and hM4Di DREADDs; water soluble version of Clozapine N-oxide (Cat. No. 4936)
alt names :
CNO (water-soluble)
storage :
Desiccate at RT
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK