dBET1 | Tocris Bioscience 6327 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

dBET1

catalog :

6327

quantity :

5 mg

price :

195 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6327

SKU :

6327/5

product name :

dBET1

description :

(+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

target :

Active Degraders

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

785.27

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PROTAC comprising BET antagonist (+)-JQ1 (Cat.No. 4499) conjugated to a cereblon E3 ubiquitin ligase ligand. Depletes BET bromodomains in cancer cell lines in vitro (EC50 = 430 nM in breast cancer cells) and induces apoptosis. Delays tumor growth and downregulates MYC in mice bearing human AML xenografts. . PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

catalog number base :

6327

product keywords :

Proteolysis Targeting Chimera PROTAC PROTACs cereblon E3 ubiquitin ligase bromodomain BRD4 targeted protein degradation tpd active degraders degrades Ubiquitin E3 Ligases Active Degraders Bromodomains 6327, target protein knockdown, PROTAC, SNIPER

extended description :

(+)-JQ1 based PROTAC targeting BET bromodomains, active in vivo

chemical name text :

(6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide

formula :

C 38 H 37 ClN 8 O 7 S

formula text :

C38H37ClN8O7S

cas num :

1799711-21-9

2020 USD :

187

2021 USD :

195 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage