product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
A 33
catalog :
6313
quantity :
10 mg
price :
169 USD
more info or order :
Tocris Bioscience product webpage
product information
brand :
Tocris
master code :
6313
SKU :
6313/10
product name :
A 33
description :
Potent and selective PDE4B inhibitor
target :
Phosphodiesterase Inhibitors
category :
Small Molecules
unit size :
10 mg
purity :
98%
observed molecular weight :
387.88
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits 100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF- production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo . Also exhibits antidepressant-like effects. Orally bioavailable.
catalog number base :
6313
product keywords :
A33 potent selective PDE4B phosphodiesterase inhibitors inhibits orally bioavailable anti-inflammatory antidepressant TBI traumatic brain injury Phosphodiesterases 6313,
extended description :
Potent and selective PDE4B inhibitor
chemical name text :
2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid
formula :
C 19 H 18 ClN 3 O 2 S
formula text :
C19H18ClN3O2S
cas num :
915082-52-9
2020 USD :
165
2021 USD :
169 USD
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK