6313/10 | Tocris Bioscience 6313/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6313/10

catalog :

6313/10

quantity :

10 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Chinn A, Salmer xf3 n C, Lee J, Sriram K, Raz E, Insel P. PDE4B Is a Homeostatic Regulator of Cyclic AMP in Dendritic Cells. Front Pharmacol. 2022;13:833832 pubmed publisher

product information

master code :

6313

SKU :

6313/10

product name :

A 33

unit size :

10 mg

description :

Potent and selective PDE4B inhibitor

target :

Phosphodiesterase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

387.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

A 33 is a potent and selective PDE4B inhibitor (IC50 = 15 nM); exhibits 100-fold selectivity for PDE4B over 4D. Regulates cAMP in inflammatory cells. Inhibits LPS-induced TNF- production and neutrophil accumulation in mouse lungs. Reduces microglial and neutrophil activation, and improves behavioral deficits in a traumatic brain injury model in vivo . Also exhibits antidepressant-like effects. Orally bioavailable.

top caption :

Potent and selective PDE4B inhibitor

extended description :

Potent and selective PDE4B inhibitor

chemical name text :

2-[4-[[2-(5-Chloro-2-thienyl)-5-ethyl-6-methyl-pyrimidin-4-yl]amino]phenyl]acetic acid

formula :

C19H18ClN3O2S

formula text :

C19H18ClN3O2S

cas num :

915082-52-9

USD :

214 USD

product details :

Potent and selective PDE4B inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage