6290/10 | Tocris Bioscience 6290/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6290/10

catalog :

6290/10

quantity :

10 mg (also 50 mg)

price :

97 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6290 - WZ 4002 C25H27ClN6O3 CAS No. 1213269-23-8

product information

master code :

6290

SKU :

6290/10

product name :

WZ 4002

unit size :

10 mg (also 50 mg)

description :

Potent mutant-selective EGFR inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

494.98

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

WZ 4002 is a potent irreversible mutant selective EGFR tyrosine kinase inhibitor. It blocks ATP-dependent autophosphorylation of EGFR carrying the T790M or L858R mutation (IC50 = 8 nM). WZ 4002 exhibits selectivity for mutant EGFR over wild-type. In mice bearing T790M mutant lung cancer cell lines WZ 4002 inhibits EGFR, AKT and ERK1/2 phosphorylation and results in significant tumor regression.

top caption :

Potent mutant-selective EGFR inhibitor

extended description :

Potent mutant-selective EGFR inhibitor

chemical name text :

N-[3-[[5-Chloro-2-[[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]oxy]phenyl]-2-propenamide

formula :

C25H27ClN6O3

formula text :

C25H27ClN6O3

cas num :

1213269-23-8

USD :

97 USD

product details :

Potent mutant-selective EGFR inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage