6278/5 | Tocris Bioscience 6278/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6278/5

catalog :

6278/5

quantity :

5 mg (also 25 mg)

price :

109 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Chipman P, Fetter R, Panzera L, Bergerson S, Karmelic D, Yokoyama S, et al. NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity. Neuron. 2022;110:3302-3317.e7 pubmed publisher
Hoffman J, Faccidomo S, Saunders B, Taylor S, Kim M, Hodge C. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration. Alcohol Clin Exp Res. 2021;45:1424-1435 pubmed publisher

image

image 1 :

Cat.No. 6278 - JNJ 55511118 C14H8ClF3N2O2 CAS No. 2036081-86-2

product information

master code :

6278

SKU :

6278/5

product name :

JNJ 55511118

unit size :

5 mg (also 25 mg)

description :

High affinity and selective negative modulator of AMPA receptors containing TARP- 8

target :

AMPA Receptor Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

328.67

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP- 8 (Ki = 26 nM). Exhibits 50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.

top caption :

High affinity and selective negative modulator of AMPA receptors containing TARP- 8

extended description :

High affinity and selective negative modulator of AMPA receptors containing TARP- 8

chemical name text :

5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one

formula :

C14H8ClF3N2O2

formula text :

C14H8ClF3N2O2

cas num :

2036081-86-2

USD :

109 USD

product details :

High affinity and selective negative modulator of AMPA receptors containing TARP- 8

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage