6272/5 | Tocris Bioscience 6272/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6272/5

catalog :

6272/5

quantity :

5 mg (also 25 mg)

price :

164 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6272 - KYP 2047 C20H25N3O2 CAS No. 796874-99-2

product information

master code :

6272

SKU :

6272/5

product name :

KYP 2047

unit size :

5 mg (also 25 mg)

description :

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

target :

Additional Synthetic Protease Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

339.44

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears -synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin 4 (T 4). Induces angiogenesis via POP inhibition. It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia. In vivo , treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline. Anti-angiogenic and neuroprotective. Brain penetrant.

top caption :

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

extended description :

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

chemical name text :

(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile

formula :

C20H25N3O2

formula text :

C20H25N3O2

cas num :

796874-99-2

USD :

164 USD

product details :

High affinity prolyl oligopeptidase inhibitor; anti-angiogenic, neuroprotective and brain penetrant

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage