6271/10 | Tocris Bioscience 6271/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6271/10

catalog :

6271/10

quantity :

10 mg (also 50 mg)

price :

178 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Johnson K, Doucette A, EDWARDS A, Verdi A, McFarland R, Hulke S, et al. Reduced activity of adenylyl cyclase 1 attenuates morphine induced hyperalgesia and inflammatory pain in mice. Front Pharmacol. 2022;13:937741 pubmed publisher
Giacoletti G, Price T, Hoelz L, Shremo Msdi A, Cossin S, Vazquez Falto K, et al. A Selective Adenylyl Cyclase 1 Inhibitor Relieves Pain Without Causing Tolerance. Front Pharmacol. 2022;13:935588 pubmed publisher
Cheng Y, Huang P, Meng B, Gan L, Wu D, Cao Y. Antinociceptive effects of the adenylyl cyclase inhibitor ST034307 on tooth-movement-induced nociception in rats. Arch Oral Biol. 2019;98:81-86 pubmed publisher

product information

master code :

6271

SKU :

6271/10

product name :

ST 034307

unit size :

10 mg (also 50 mg)

description :

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

target :

Adenylyl Cyclase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

297.95

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ST 034307 is an adenylyl cyclase 1 (AC1) inhibitor (IC50 = 2.3 M). Exhibits some selectivity for AC1 over other AC isoforms, with no significant activity against AC8. Inhibits Ca2+/calmodulin-stimulated cAMP accumulation in hippocampal homogenates. Enhances opioid receptor (MOR)-mediated inhibition of AC1 in cellular assays and inhibits development and maintenance of MOR-mediated sensitization of AC1. ST 034307 relieves pain without causing tolerance in mouse models of pain. Active in vivo . Analgesic.

top caption :

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

extended description :

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

chemical name text :

6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one

formula :

C10H4Cl4O2

formula text :

C10H4Cl4O2

cas num :

133406-29-8

USD :

178 USD

product details :

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage