Lonafarnib | Tocris Bioscience 6265 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Lonafarnib

catalog :

6265

quantity :

10 mg (also 50 mg)

price :

135 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6265

SKU :

6265/10

product name :

Lonafarnib

description :

Potent farnesyltransferase inhibitor

target :

Protein Prenyltransferase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

638.82

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent farnesyl transferase inhibitor (IC50 = 1.9 nM). Inhibits farnesylation of RAS. Also inhibits Pgp transport (IC50 < 3 M) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates. Inhibits neovascularization by affecting cell motility. Orally bioavailable.

catalog number base :

6265

product keywords :

Lonafarnib SCH66336 farnesyl transferase inhibitors inhibits PgP transport anticancer neovascularization orally bioavailable Protein Prenyltransferases Post-translational Modifications 6265,

extended description :

Potent farnesyltransferase inhibitor

chemical name text :

4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide

formula :

C 27 H 31 Br 2 ClN 4 O 2

formula text :

C27H31Br2ClN4O2

cas num :

193275-84-2

2020 USD :

129

2021 USD :

135 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage