6265/10 | Tocris Bioscience 6265/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6265/10

catalog :

6265/10

quantity :

10 mg (also 50 mg)

price :

170 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Danielsson B, Peters H, Bathula K, Spear L, Noll N, Dahl K, et al. Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress. Biophys J. 2022;: pubmed publisher

image

image 1 :

Cat.No. 6265 - Lonafarnib C27H31Br2ClN4O2 CAS No. 193275-84-2

product information

master code :

6265

SKU :

6265/10

product name :

Lonafarnib

unit size :

10 mg (also 50 mg)

description :

Potent farnesyltransferase inhibitor

target :

Protein Prenyltransferase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

638.82

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lonafarnib is a potent farnesyl transferase inhibitor (IC50 = 1.9 nM). Inhibits farnesylation of RAS. Also inhibits Pgp transport (IC50 < 3 M) and increases potency and anticancer activity when used in conjunction with cytotoxic Pgp substrates. Inhibits neovascularization by affecting cell motility. Orally bioavailable.

top caption :

Potent farnesyltransferase inhibitor

extended description :

Potent farnesyltransferase inhibitor

chemical name text :

4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide

formula :

C27H31Br2ClN4O2

formula text :

C27H31Br2ClN4O2

cas num :

193275-84-2

USD :

170 USD

product details :

Potent farnesyltransferase inhibitor

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage