6261/10 | Tocris Bioscience 6261/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6261/10

catalog :

6261/10

quantity :

10 mg (also 50 mg)

price :

189 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6261 - VCP 171 C18H12F3NOS CAS No. 1018830-99-3

product information

master code :

6261

SKU :

6261/10

product name :

VCP 171

unit size :

10 mg (also 50 mg)

description :

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

target :

Adenosine A1 Receptor Modulators

category :

Small Molecules

purity :

98%

observed molecular weight :

347.35

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

VCP 171 is an adenosine A1 receptor positive allosteric modulator (PAM) (pKB = 5.65, binding cooperativity with NECA 0.68). In absence of orthosteric agonist, VCP171 behaves as an allosteric partial agonist, inhibiting cAMP activity. Inhibits AMPA receptor-mediated evoked excitatory postsynaptic current (eEPSC) amplitude in lamina I and II neurons in a rat partial nerve-injury model of neuropathic pain.

top caption :

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

extended description :

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

chemical name text :

[2-Amino-4-[3-(trifluoromethyl)phenyl]-3-thienyl]phenylmethanone

formula :

C18H12F3NOS

formula text :

C18H12F3NOS

cas num :

1018830-99-3

USD :

189 USD

product details :

Positive allosteric modulator (PAM) of A1 receptors; also allosteric partial agonist in absence of orthosteric agonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage