6251/10 | Tocris Bioscience 6251/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6251/10

catalog :

6251/10

quantity :

10 mg (also 50 mg)

price :

190 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Pavlou S, Foskolou S, Patikas N, Field S, Papachristou E, Santos C, et al. CRISPR-Cas9 genetic screen leads to the discovery of L-Moses, a KAT2B inhibitor that attenuates Tunicamycin-mediated neuronal cell death. Sci Rep. 2023;13:3934 pubmed publisher

image

image 1 :

Cat.No. 6251 - L Moses dihydrochloride C21H24N6.2HCl

product information

master code :

6251

SKU :

6251/10

product name :

L Moses dihydrochloride

unit size :

10 mg (also 50 mg)

description :

High affinity and selective PCAF bromodomain inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

433.38

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

L Moses dihydrochloride is a high affinity and selective cell-permeable p300/CBP-associated factor (PCAF) inhibitor (Ki = 47 nM), which exhibits no significant activity against a panel of 48 other bromodomains except GCN5 (Kd = 600 nM). L Moses exhibits 4500-fold selectivity for PCAF over BRD4. The compound inhibits Tunicamycin (Cat. No. 3516) -induced neuronal cell death by reversing the transcriptional changes associated with Tunicamycin treatment. L Moses exhibits metabolic stability in mouse and human liver microsomes and no observable cytotoxicity in peripheral blood mononuclear cells (PBMC).

top caption :

High affinity and selective PCAF bromodomain inhibitor

extended description :

High affinity and selective PCAF bromodomain inhibitor

chemical name text :

(1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride

formula :

C21H24N6.2HCl

formula text :

C21H24N6.2HCl

cas num :

2922480-38-2

USD :

190 USD

product details :

High affinity and selective PCAF bromodomain inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage