SM 16 | Tocris Bioscience 6245 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SM 16

catalog :

6245

quantity :

10 mg

price :

300 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6245

SKU :

6245/10

product name :

SM 16

description :

Potent TGF- RI inhibitor; orally bioavailable

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

430.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent TGF- receptor type 1 (TGF- RI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF- RI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF- signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.

catalog number base :

6245

product keywords :

SM16 TGF-beta transforming growth factor beta inhibitors inhibits ALK5 ALK4 orally bioavailable TGF-beta Receptors 6245,

extended description :

Potent TGF- RI inhibitor; orally bioavailable

chemical name text :

4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide

formula :

C 25 H 26 N 4 O 3

formula text :

C25H26N4O3

cas num :

614749-78-9

2020 USD :

285

2021 USD :

300 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage