6245/10 | Tocris Bioscience 6245/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

6245/10

catalog :

6245/10

quantity :

10 mg

price :

335 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6245 - SM 16 C25H26N4O3 CAS No. 614749-78-9

product information

master code :

6245

SKU :

6245/10

product name :

SM 16

unit size :

10 mg

description :

Potent TGF- RI inhibitor; orally bioavailable

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

430.5

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SM 16 is a potent TGF- receptor type 1 (TGF- RI) inhibitor (IC50 = 64 nM in luciferase assay). Selective for TGF- RI over other ALK family members. Decreases Smad phosphorylation and inhibits tumor growth in a mouse xenograft model. Attenuates increased TGF- signaling in retinal vessels of diabetic rats. Also prevents intimal thickening and vascular remodeling in rat carotid balloon injury model. Orally bioavailable.

top caption :

Potent TGF- RI inhibitor; orally bioavailable

extended description :

Potent TGF- RI inhibitor; orally bioavailable

chemical name text :

4-[4-(1,3-Benzodioxol-5-yl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-2-yl]bicyclo[2.2.2]octane-1-carboxamide

formula :

C25H26N4O3

formula text :

C25H26N4O3

cas num :

614749-78-9

USD :

335 USD

product details :

Potent TGF- RI inhibitor; orally bioavailable

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage