chemical

PKRA 7

6238

5 mg

155 USD

6238

6238/5

PKRA 7

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

Prokineticin R2/PROKR2

Small Molecules

5 mg

128674

98%

541.48

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Potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1 and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo . Brain penetrant. Cell-permeable.

6238

1233926-87-8 PKRA7 PKRA_7 potent prokineticin2 PROK2 PK2 Bv8 PROKR1 PKR1 PKR2 antagonists antagonises antagonizes antagonism brain penetrant PROK2 Antagonist Bv8 Antagonist PK2 Antagonist Prokineticin 2 Antagonist Other Peptide Receptors 6238, ProkineticinR2, Prokineticin Receptor 2, PROKR 2, PROK R2, PKR 2, G-protein coupled receptor 73-like 1, G protein-coupled receptor 73-like 1, neuropeptide Y receptor activity, leucokinin receptor, Lkr, hypogonadism, GPCR, G Protein-Coupled Receptor

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

(3R)-N-[(9-Chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride

C 27 H 34 ClFN 2 O 4 .HCl

C27H34ClFN2O4.HCl

155

155 USD

dJ680N4.3, G protein-coupled receptor 73-like 1, GPR73, GPR73a, GPR73bG-protein coupled receptor 73-like 1, GPR73L1, GPR73L1Kallmann syndrome 3 (autosomal dominant), GPRg2, GPRg2KAL3, KAL3, PKR1, PKR2, PKR2PK-R2, prokineticin receptor 2, ProkineticinR1, ProkineticinR2, PROKR1, PROKR2, ZAQ, PROK2 Antagonist, Bv8 Antagonist, PK2 Antagonist, Prokineticin 2 Antagonist

Store at -20°C