product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
PKRA 7
catalog :
6238/5
quantity :
5 mg
price :
195 USD
more info or order :
Tocris Bioscience product webpage
image
image 1 :
Tocris Bioscience 6238/5 image 1
Cat.No. 6238 - PKRA 7 C27H34ClFN2O4.HCl
product information
brand :
Tocris
catalog number base :
6238
SKU :
6238/5
product name :
PKRA 7
units size :
5 mg
description :
Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant
target :
Prokineticin Receptor Antagonists
category :
Small Molecules
purity :
98%
observed molecular weight :
541.48
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
PKRA 7 is a potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1 and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo . Brain penetrant. Cell-permeable.
top caption :
Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant
extended description :
Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant
chemical name text :
(3R)-N-[(9-Chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride
formula :
C27H34ClFN2O4.HCl
formula text :
C27H34ClFN2O4.HCl
USD :
195 USD
product details :
Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant
alt names :
PROK2 Antagonist,Bv8 Antagonist,PK2 Antagonist,Prokineticin 2 Antagonist
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK