PKRA 7 | Tocris Bioscience 6238/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PKRA 7

catalog :

6238/5

quantity :

5 mg

price :

195 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6238 - PKRA 7 C27H34ClFN2O4.HCl

product information

brand :

Tocris

master code :

6238

SKU :

6238/5

product name :

PKRA 7

unit size :

5 mg

seo description :

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

target :

Prokineticin R2/PROKR2

category :

Small Molecules

purity :

98%

observed molecular weight :

541.48

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PKRA 7 is a potent prokineticin (PK) receptor antagonist (IC50 values are 5.0 and 8.2 nM for PKR1 and PKR2, respectively). Reduces IL-1 and lL-6 expression in the joints and suppresses severity of arthritis in a mouse model of rheumatoid arthritis. Inhibits PK2-induced expression of pro-migratory chemokines and chemokine receptors in macrophages. Exhibits antitumor activity against glioblastoma and pancreatic cancer xenograft tumor models. Also exhibits antiangiogenic activity in vivo . Brain penetrant. Cell-permeable.

top caption :

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

extended description :

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

chemical name text :

(3R)-N-[(9-Chloro-3,4-dihydro-2H-1,5-benzodioxepin-7-yl)methyl]-1-[(4-fluoro-3-methoxyphenyl)methyl]-N-(2-methylpropyl)-3-pyrrolidinecarboxamide hydrochloride

formula :

C27H34ClFN2O4.HCl

formula text :

C27H34ClFN2O4.HCl

USD :

195 USD

product details :

Potent prokineticin (PK) 1 and 2 receptor antagonist; antitumor; BBB penetrant

alt names :

BV8, dJ680N4.3, EGVEGF, G protein-coupled receptor 73-like 1, GPR73, GPR73a, GPR73bG-protein coupled receptor 73-like 1, GPR73L1, GPR73L1Kallmann syndrome 3 (autosomal dominant), GPRg2, GPRg2KAL3, KAL3, PKR1, PKR2, PKR2PK-R2, PROK1, PROK2, Prokineticin 1, prokineticin receptor 2, ProkineticinR1, ProkineticinR2, PROKR1, PROKR2, Protein Bv8 homolog, ZAQ, PROK2 Antagonist,Bv8 Antagonist,PK2 Antagonist,Prokineticin 2 Antagonist

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage