FPS ZM1 | Tocris Bioscience 6237/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FPS ZM1

catalog :

6237/10

quantity :

10 mg (also 50 mg)

price :

89 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Costa D, Moura Neto V, Bolick D, Guerrant R, Fawad J, Shin J, et al. S100B Inhibition Attenuates Intestinal Damage and Diarrhea Severity During Clostridioides difficile Infection by Modulating Inflammatory Response. Front Cell Infect Microbiol. 2021;11:739874 pubmed publisher
Wang C, Wang X, Han A, Wang Y, Jiang H. Proof-of-concept study investigating the role of S100P-RAGE in nasopharyngeal carcinoma. Exp Ther Med. 2021;21:470 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher

product information

brand :

Tocris

master code :

6237

SKU :

6237/10

product name :

FPS ZM1

unit size :

10 mg (also 50 mg)

seo description :

High affinity antagonist of RAGE

target :

NFkB/IkB Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

327.85

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FPS ZM1 is a high affinity antagonist of the receptor for advanced glycation end products (RAGE) (Ki = 25 nM). Blocks A binding to the V domain of RAGE and inhibits A 40- and A 42-induced cellular stress in RAGE-expressing cells in vitro and in the mouse brain in vivo . Blocks -secretase activity, A production, microglia activation and neuroinflammation in vivo . BBB permeable.

top caption :

High affinity antagonist of RAGE

extended description :

High affinity antagonist of RAGE

chemical name text :

4-Chloro-N-cyclohexyl-N-(phenylmethyl)benzamide

formula :

C20H22ClNO

formula text :

C20H22ClNO

cas num :

945714-67-0

USD :

89 USD

product details :

High affinity antagonist of RAGE

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage