Dacomitinib | Tocris Bioscience 6231 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dacomitinib

catalog :

6231

quantity :

10 mg (also 50 mg)

price :

248 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6231

SKU :

6231/10

product name :

Dacomitinib

description :

Potent irreversible pan ErbB inhibitor

target :

EGF Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

469.94

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent irreversible pan ErbB inhibitor (IC50 values are 6.0, 45.7 and 73.7 nM for EGFR, ERBB2 and ERBB4, respectively). Inhibits mutant and wild type forms of ErbB, including EGFR T780M, and shows activity in NSCLC cell lines sensitive and resistant to Iressa (Cat.No. 3000). Inhibits tumor growth. Orally bioavailable.

catalog number base :

6231

product keywords :

Dacomitinib ErbB inhibitors inhibits EGFR ERBB2 ERBB4 potent irreversible pan-ErbB cancer orally bioavailable PF00299804 EGFR 6231,

extended description :

Potent irreversible pan ErbB inhibitor

chemical name text :

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide

formula :

C 24 H 25 ClFN 5 O 2

formula text :

C24H25ClFN5O2

cas num :

1110813-31-4

2020 USD :

243

2021 USD :

248 USD

alt names :

PF00299804

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage