PFM 01 | Tocris Bioscience 6222/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PFM 01

catalog :

6222/10

quantity :

10 mg (also 50 mg)

price :

95 USD

citations: 2

Reference
Dhoonmoon A, Nicolae C, Moldovan G. The KU-PARP14 axis differentially regulates DNA resection at stalled replication forks by MRE11 and EXO1. Nat Commun. 2022;13:5063 pubmed publisher
Kilgas S, Singh A, Paillas S, Then C, Torrecilla I, Nicholson J, et al. p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation. Cell Rep. 2021;35:109153 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

6222

SKU :

6222/10

product name :

PFM 01

Description :

MRE11 endonuclease inhibitor

target :

Endonuclease Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

293.4

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PFM 01 is a MRE11 endonuclease inhibitor. Prevents double-stranded break (DSB) resection. Enhances non-homologous end-joining (NHEJ) and reduces homologous recombination.

extended description :

MRE11 endonuclease inhibitor

chemical name text :

(5Z)-5-[(4-Hydroxyphenyl)methylene]-3-(2-methylpropyl)-2-thioxo-4-thiazolidinone

formula :

C 14 H 15 NO 2 S 2

formula text :

C14H15NO2S2

cas num :

1558598-41-6

USD :

95 USD

product details :

MRE11 endonuclease inhibitor

storage :

Store at -20°C