MS 275 | Tocris Bioscience 6208 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MS 275

catalog :

6208

quantity :

10 mg (also 50 mg)

price :

134 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Kim D, Dunleavey J, Xiao L, Ollila D, Troester M, Otey C, et al. Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition. Br J Cancer. 2018;118:1359-1368 pubmed publisher

product information

brand :

Tocris

master code :

6208

SKU :

6208/10

product name :

MS 275

description :

HDAC (Class I) inhibitor

target :

Class I Histone Deacetylases Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

376.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Class I HDAC inhibitor (IC50 values are 0.18, 0.74, 44.9 and 100 M for HDAC1, 3, 8 and 6, respectively). Exhibits antiproliferative effects and induces apoptosis in a range of tumor cell lines in vitro and in vivo . Increases estrogen receptor - and aromatase expression in breast cancer cells. Inhibits PCB-induced neuronal cell death by preventing HDAC3 binding and histone deacetylation within the synapsin-1 promoter.

catalog number base :

6208

product keywords :

MS275 HDAC1 HDAC3 inhibits inhibitors class I histone deacetylases SNDX275 entinostat SNDX 275 Class I HDACs 6208,

extended description :

HDAC (Class I) inhibitor

chemical name text :

(Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate

formula :

C 21 H 20 N 4 O 3

formula text :

C21H20N4O3

cas num :

209783-80-2

2020 USD :

130

2021 USD :

134 USD

alt names :

entinostat, SNDX 275

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage