BAY 876 | Tocris Bioscience 6199/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

BAY 876

catalog :

6199/5

quantity :

5 mg (also 25 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Williams L, Fujimoto T, Weaver R, Logsdon A, Evitts K, Young J, et al. Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu. Fluids Barriers CNS. 2022;19:10 pubmed publisher
Kim M, Ly S, Xie Y, Duronio G, Ford Roshon D, Hwang J, et al. YAP1 and PRDM14 converge to promote cell survival and tumorigenesis. Dev Cell. 2022;57:212-227.e8 pubmed publisher

image

image 1 :

Cat.No. 6199 - BAY 876 C24H16F4N6O2 CAS No. 1799753-84-6

product information

brand :

Tocris

master code :

6199

SKU :

6199/5

product name :

BAY 876

unit size :

5 mg (also 25 mg)

seo description :

Potent and selective GLUT1 inhibitor

target :

Glucose Transporter Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

496.42

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

BAY 876 is a potent and selective GLUT1 inhibitor (IC50 = 2 nM) that displays selectivity for GLUT1 over GLUT2/3/4 (IC50 values are 10.8, 1.67 and 0.29 M, respectively). BAY 876 induces cell death in hypoxic conditions in vitro and inhibits glucose uptake by Hela-MaTu cells. In ovarian cancer, BAY 876 reduces glycolysis rates and ATP production and inhibits proliferation in vitro and in vivo . This compound is cell permeable and orally bioavailable.

top caption :

Potent and selective GLUT1 inhibitor

extended description :

Potent and selective GLUT1 inhibitor

chemical name text :

N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

formula :

C24H16F4N6O2

formula text :

C24H16F4N6O2

cas num :

1799753-84-6

USD :

169 USD

product details :

Potent and selective GLUT1 inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage