Brequinar sodium | Tocris Bioscience 6196 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Brequinar sodium

catalog :

6196

quantity :

10 mg (also 50 mg)

price :

104 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6196

SKU :

6196/10

product name :

Brequinar sodium

description :

Potent and selective DHODH inhibitor

target :

Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

397.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of 400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 M. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo . Antimetabolite.

catalog number base :

6196

product keywords :

NSC368390 DuP785 BRQ Biphenquinate Brequinar potent selective DHODH inhibitors inhibits dihydroorotate dehydrogenase AML acute myeloid leukemia BRQ DuP 785 NSC 368390 Dihyroorotate Dehydrogenase DNA, RNA and Protein Synthesis 6196, DHODH Inhibitor, Dihydroorotate Dehydrogenase Inhibitor, Dihydroorotate Dehydrogenase Inhibitors, Dihydroorotate Oxidase, DHOdehase, POADS, URA1

extended description :

Potent and selective DHODH inhibitor

chemical name text :

6-Fluoro-2-(2 -fluoro[1,1 -biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium

formula :

C 23 H 14 F 2 NO 2 Na

formula text :

C23H14F2NO2Na

cas num :

96201-88-6

2020 USD :

2021 USD :

104 USD

alt names :

BRQ, DuP 785, NSC 368390

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage