Brequinar sodium | Tocris Bioscience 6196/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Brequinar sodium

catalog :

6196/10

quantity :

10 mg (also 50 mg)

price :

134 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Alkasalias T, Zhang J, Madapura H, Dalarun B, Reina O, Lewensohn R, et al. Proof-of-principle studies on a strategy to enhance nucleotide imbalance specifically in cancer cells. Cell Death Discov. 2022;8:464 pubmed publisher
Zhang J, Terán G, Popa M, Madapura H, Ladds M, Lianoudaki D, et al. DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance. iScience. 2021;24:102494 pubmed publisher
Lafita Navarro M, Venkateswaran N, Kilgore J, Kanji S, Han J, Barnes S, et al. Inhibition of the de novo pyrimidine biosynthesis pathway limits ribosomal RNA transcription causing nucleolar stress in glioblastoma cells. PLoS Genet. 2020;16:e1009117 pubmed publisher

product information

brand :

Tocris

master code :

6196

SKU :

6196/10

product name :

Brequinar sodium

unit size :

10 mg (also 50 mg)

seo description :

Potent and selective DHODH inhibitor

target :

DHODH Inhibitors

category :

Small Molecules

purity :

99%

observed molecular weight :

397.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Brequinar sodium is a potent and selective dihydroorotate dehydrogenase (DHODH) inhibitor (IC50 = ~20 nM). Causes depletion of pyrimidine nucleotides. Exhibits minimal inhibition against a panel of 400 kinases. Triggers differentiation of AML cell lines (ED50 = ~ 1 M. Note uridine concentration effects ED50 value). Causes differentiation and depletion of leukemia-initiating cells in vivo . Antimetabolite.

top caption :

Potent and selective DHODH inhibitor

extended description :

Potent and selective DHODH inhibitor

chemical name text :

6-Fluoro-2-(2 -fluoro[1,1 -biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium

formula :

C23H14F2NO2Na

formula text :

C23H14F2NO2Na

cas num :

96201-88-6

USD :

134 USD

product details :

Potent and selective DHODH inhibitor

alt names :

BRQ,DuP 785,NSC 368390

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage