SSR 149415 | Tocris Bioscience 6195/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SSR 149415

catalog :

6195/10

quantity :

10 mg (also 50 mg)

price :

271 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Lukoyanov N, Watanabe H, Carvalho L, Kononenko O, Sarkisyan D, Zhang M, et al. Left-right side-specific endocrine signaling complements neural pathways to mediate acute asymmetric effects of brain injury. elife. 2021;10: pubmed publisher
Tong S, Lee H, Lee Y, Wu L, Tsou Y, Lu S, et al. Arginine Vasopressin Modulates Ion and Acid/Base Balance by Regulating Cell Numbers of Sodium Chloride Cotransporter and H+-ATPase Rich Ionocytes. Int J Mol Sci. 2020;21: pubmed publisher

image

image 1 :

Cat.No. 6195 - SSR 149415 C30H32ClN3O8S CAS No. 439687-69-1

product information

brand :

Tocris

master code :

6195

SKU :

6195/10

product name :

SSR 149415

unit size :

10 mg (also 50 mg)

seo description :

Potent and selective vasopressin V1B antagonist

target :

Vasopressin Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

630.11

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SSR 149415 is a potent and selective vasopressin V1B antagonist (Ki values are 3.7 and 1.3 nM for native and recombinant rat V1b receptors, respectively). Displays 70-fold selectively for rat V1B over V1A, V2 oxytoxin and a range of other receptors and ion channels. Inhibits AVP-induced glucagon release in In-R1-G9 -pancreatic cells in vitro . Inhibits stress-induced ACTH release and exhibits anxiolytic-like effects in anxiety models. Orally bioavailable.

top caption :

Potent and selective vasopressin V1B antagonist

extended description :

Potent and selective vasopressin V1B antagonist

chemical name text :

(2S,4R)-1-[(3R)-5-Chloro-1-[(2,4-dimethoxyphenyl)sulfonyl]-2,3-dihydro-3-(2-methoxyphenyl)-2-oxo-1H-indol-3-yl]-4-hydroxy-N,N-dimethyl-2-pyrrolidinecarboxamide

formula :

C30H32ClN3O8S

formula text :

C30H32ClN3O8S

cas num :

439687-69-1

USD :

271 USD

product details :

Potent and selective vasopressin V1B antagonist

alt names :

Nelivaptan

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage