TM 5441 | Tocris Bioscience 6194 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TM 5441

catalog :

6194

quantity :

10 mg (also 50 mg)

price :

203 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Eren M, Boe A, Murphy S, Place A, Nagpal V, Morales Nebreda L, et al. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 2014;111:7090-5 pubmed publisher

product information

brand :

Tocris

master code :

6194

SKU :

6194/10

product name :

TM 5441

description :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

target :

PAI-1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

450.8

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 M). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

catalog number base :

6194

product keywords :

TM5441 PAI-1 inhibitor inhibits cancer apoptosis senescence ageing blood pressure telomere hypertrophy renoprotective orally bioavailable Plasminogen Activator Inhibitor 1 6194, p21-Activated Kinases, p21-Activated Kinase, PAKs

extended description :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

chemical name text :

5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

formula :

C 21 H 16 ClN 2 NaO 6

formula text :

C21H16ClN2NaO6

2020 USD :

197

2021 USD :

203 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage