TM 5441 | Tocris Bioscience 6194/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TM 5441

catalog :

6194/10

quantity :

10 mg (also 50 mg)

price :

256 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Eren M, Boe A, Murphy S, Place A, Nagpal V, Morales Nebreda L, et al. PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice. Proc Natl Acad Sci U S A. 2014;111:7090-5 pubmed publisher

product information

brand :

Tocris

master code :

6194

SKU :

6194/10

product name :

TM 5441

unit size :

10 mg (also 50 mg)

seo description :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

target :

PAI-1 Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

450.8

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TM 5441 is a plasminogen activator inhibitor-1 (PAI-1) inhibitor (IC50 = 3.58 - 60.3 M). Increases apoptosis in human cancer cell lines. Reduces senescence and increases lifespan in mouse models of ageing (kl/kl). Inhibits L-NAME (Cat.No. 0665) induced systolic blood pressure increases, telomere length reduction and cardiac hypertrophy in mice. Renoprotective. Orally bioavailable.

top caption :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

extended description :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

chemical name text :

5-Chloro-2-[[2-[2-[[3-(3-furanyl)phenyl]amino]-2-oxoethoxy]acetyl]amino]benzoic acid sodium salt

formula :

C21H16ClN2NaO6

formula text :

C21H16ClN2NaO6

cas num :

2319722-53-5

USD :

256 USD

product details :

Plasminogen activator inhibitor-1 (PAI-1) inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage