NMS 873 | Tocris Bioscience 6180 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NMS 873

catalog :

6180

quantity :

25 mg

price :

364 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Magnaghi P, D Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013;9:548-56 pubmed publisher

product information

brand :

Tocris

master code :

6180

SKU :

6180/25

product name :

NMS 873

description :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

520.67

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 10 M). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.

catalog number base :

6180

product keywords :

NMS873 Potent selective valosine containing protein VCP p97 allosteric inhibitors inhibits unfolded protein response UPR autophagosome maturation antiproliferative anticancer Autophagy Other ER stress/UPR p97 ATPase Translocation, Exocytosis & Endocytosis Translocation 6180,

extended description :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

chemical name text :

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4 -(methylsulfonyl)[1,1 -biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

formula :

C 27 H 28 N 4 O 3 S 2

formula text :

C27H28N4O3S2

cas num :

1418013-75-8

2020 USD :

350

2021 USD :

364 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage