NMS 873 | Tocris Bioscience 6180/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NMS 873

catalog :

6180/5

quantity :

5 mg (also 25 mg)

price :

122 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Wrobel L, Hill S, Djajadikerta A, Fernandez Estévez M, Karabiyik C, Ashkenazi A, et al. Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearance. Nat Commun. 2022;13:4146 pubmed publisher
Franz A, Valledor P, Ubieto Capella P, Pilger D, Galarreta A, Lafarga V, et al. USP7 and VCPFAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork. Cell Rep. 2021;37:109819 pubmed publisher
Huang J, Zhou Q, Gao M, Nowsheen S, Zhao F, Kim W, et al. Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging. Mol Cell. 2020;79:824-835.e5 pubmed publisher
Pradeep Yeola A, Akbar I, Baillargeon J, Mercy Ignatius Arokia Doss P, Paavilainen V, Rangachari M. Protein translocation and retro-translocation across the endoplasmic reticulum are crucial to inflammatory effector CD4+ T cell function. Cytokine. 2020;129:154944 pubmed publisher
Magnaghi P, D Alessio R, Valsasina B, Avanzi N, Rizzi S, Asa D, et al. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol. 2013;9:548-56 pubmed publisher

product information

brand :

Tocris

master code :

6180

SKU :

6180/5

product name :

NMS 873

unit size :

5 mg (also 25 mg)

seo description :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

520.67

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NMS 873 is a potent p97 ATPase (VCP) allosteric inhibitor (IC50 = 30 nM). Selective over all other AAA ATPases, HSP90 and kinases tested (IC50 10 M). Activates the unfolded protein response (UPR) and modulates autophagosome maturation. Exhibits antiproliferative activity in cancer cells in vitro (IC50 values are 400 and 700 nM for HCT116 and HeLa cells respectively). Reduces p97-sensitization to trypsin digestion.

top caption :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

extended description :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

chemical name text :

3-[3-(Cyclopentylthio)-5-[[[2-methyl-4 -(methylsulfonyl)[1,1 -biphenyl]-4-yl]oxy]methyl]-4H-1,2,4-triazol-4-yl]pyridine

formula :

C27H28N4O3S2

formula text :

C27H28N4O3S2

cas num :

1418013-75-8

USD :

122 USD

product details :

Potent and selective p97 ATPase (VCP) allosteric inhibitor

storage :

Store at +4░C

more info or order :

Tocris Bioscience product webpage