FTY 720 | Tocris Bioscience 6176 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FTY 720

catalog :

6176

quantity :

10 mg (also 50 mg)

price :

97 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra S, et al. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019;5:eaaw7243 pubmed publisher
Yuan X, Wang X, Gu B, Ma Y, Liu Y, Sun M, et al. Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex. Neoplasia. 2017;19:868-884 pubmed publisher

product information

brand :

Tocris

master code :

6176

SKU :

6176/10

product name :

FTY 720

description :

Potent S1P receptor agonist; also immunosuppressant

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

343.93

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

catalog number base :

6176

product keywords :

FTY720 Fingolimod Gilenya S1P receptors agonists sphingosine-1-phosphate immunosuppresent sequesters lymphocytes orally bioavailable BBB blood-brain barrier permeable Fingolimod Gilenya Sphingosine-1-phosphate Receptors Immunosuppressants 6176,

extended description :

Potent S1P receptor agonist; also immunosuppressant

chemical name text :

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

formula :

C 19 H 33 NO 2 .HCl

formula text :

C19H33NO2.HCl

cas num :

162359-56-0

2020 USD :

2021 USD :

97 USD

alt names :

Fingolimod, Gilenya

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage