FTY 720 | Tocris Bioscience 6176/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FTY 720

catalog :

6176/10

quantity :

10 mg (also 50 mg)

price :

127 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Bruno G, Nastasi N, Subbiani A, Boaretto A, Ciullini Mannurita S, Mattei G, et al. β3-adrenergic receptor on tumor-infiltrating lymphocytes sustains IFN-γ-dependent PD-L1 expression and impairs anti-tumor immunity in neuroblastoma. Cancer Gene Ther. 2023;30:890-904 pubmed publisher
Choa R, Tohyama J, Wada S, Meng H, Hu J, Okumura M, et al. Thymic stromal lymphopoietin induces adipose loss through sebum hypersecretion. Science. 2021;373: pubmed publisher
Zhao R, Afthinos A, Zhu T, Mistriotis P, Li Y, Serra S, et al. Cell sensing and decision-making in confinement: The role of TRPM7 in a tug of war between hydraulic pressure and cross-sectional area. Sci Adv. 2019;5:eaaw7243 pubmed publisher
Yuan X, Wang X, Gu B, Ma Y, Liu Y, Sun M, et al. Directional Migration in Esophageal Squamous Cell Carcinoma (ESCC) is Epigenetically Regulated by SET Nuclear Oncogene, a Member of the Inhibitor of Histone Acetyltransferase Complex. Neoplasia. 2017;19:868-884 pubmed publisher
Samarska I, Bouma H, Buikema H, Mungroop H, Houwertjes M, Absalom A, et al. S1P1 receptor modulation preserves vascular function in mesenteric and coronary arteries after CPB in the rat independent of depletion of lymphocytes. PLoS ONE. 2014;9:e97196 pubmed publisher

product information

brand :

Tocris

master code :

6176

SKU :

6176/10

product name :

FTY 720

unit size :

10 mg (also 50 mg)

seo description :

Potent S1P receptor agonist; also immunosuppressant

target :

Sphingosine-1-phosphate Receptor Agonists

category :

Small Molecules

purity :

99%

observed molecular weight :

343.93

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FTY 720 is an S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppressant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable.

top caption :

Potent S1P receptor agonist; also immunosuppressant

extended description :

Potent S1P receptor agonist; also immunosuppressant

chemical name text :

2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride

formula :

C19H33NO2.HCl

formula text :

C19H33NO2.HCl

cas num :

162359-56-0

USD :

127 USD

product details :

Potent S1P receptor agonist; also immunosuppressant

alt names :

Fingolimod,Gilenya

storage :

Store at -20░C

more info or order :

Tocris Bioscience product webpage