INF 4E | Tocris Bioscience 6172 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

INF 4E

catalog :

6172

quantity :

10 mg

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Cocco M, Garella D, Di Stilo A, Borretto E, Stevanato L, Giorgis M, et al. Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis. J Med Chem. 2014;57:10366-82 pubmed publisher

product information

brand :

Tocris

master code :

6172

SKU :

6172/10

product name :

INF 4E

description :

Caspase-1 and NLRP3 inflammasome inhibitor

target :

Inflammasomes Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

240.68

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NLRP3 inflammasome and caspase-1 inhibitor (Ki = 9.6 M for caspase-1). Inhibits Nigericin (Cat. No. 4312) or ATP (Cat.No. 3245) induced pyroptosis of PMA-differentiated and LPS-primed THP-1 cells and activates the Keap1-Nrf2 pathway.

catalog number base :

6172

product keywords :

INF4E NLRP3 inflammasomes caspases 1 inhibitors inhibits pyroptosis nrf2 Caspases Inflammasomes Nrf2 6172,

extended description :

Caspase-1 and NLRP3 inflammasome inhibitor

chemical name text :

Ethyl 2[(2-chlorophenyl)(hydroxy)methyl]acrylate

formula :

C 12 H 13 ClO 3

formula text :

C12H13ClO3

cas num :

88039-46-7

2020 USD :

201

2021 USD :

208 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage