product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
Cinacalcet hydrochloride
catalog :
6170/10
quantity :
10 mg (also 50 mg)
price :
122 USD
more info or order :
Tocris Bioscience product webpage
citations: 2
Reference
Dowsett L, Duluc L, Higgins E, Alghamdi F, Fast W, Salt I, et al. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cell Signal. 2023;107:110676 pubmed publisher
Zhang C, Kaye J, Cai Z, Wang Y, Prescott S, Liberles S. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021;109:461-472.e5 pubmed publisher
image
image 1 :
Tocris Bioscience 6170/10 image 1
Cat.No. 6170 - Cinacalcet hydrochloride C22H22F3N.HCl CAS No. 364782-34-3
product information
brand :
Tocris
catalog number base :
6170
SKU :
6170/10
product name :
Cinacalcet hydrochloride
units size :
10 mg (also 50 mg)
description :
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
target :
Calcium-Sensing Receptor Agonists
category :
Small Molecules
purity :
98%
observed molecular weight :
393.87
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.
top caption :
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
extended description :
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
chemical name text :
N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride
formula :
C22H22F3N.HCl
formula text :
C22H22F3N.HCl
cas num :
364782-34-3
USD :
122 USD
product details :
Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable
alt names :
AMG 073
storage :
Store at -20°C
more info or order :
Tocris Bioscience product webpage
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK