Cinacalcet hydrochloride | Tocris Bioscience 6170/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Cinacalcet hydrochloride

catalog :

6170/10

quantity :

10 mg (also 50 mg)

price :

122 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Dowsett L, Duluc L, Higgins E, Alghamdi F, Fast W, Salt I, et al. Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cell Signal. 2023;107:110676 pubmed publisher
Zhang C, Kaye J, Cai Z, Wang Y, Prescott S, Liberles S. Area Postrema Cell Types that Mediate Nausea-Associated Behaviors. Neuron. 2021;109:461-472.e5 pubmed publisher

image

image 1 :

Cat.No. 6170 - Cinacalcet hydrochloride C22H22F3N.HCl CAS No. 364782-34-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6170

SKU :

6170/10

product name :

Cinacalcet hydrochloride

description :

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

target :

Calcium-Sensing Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

393.87

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cinacalcet hydrochloride is a calcium-sensing receptor (CaSR) allosteric agonist. Activates CaSR signaling in cellular proliferation and phosphatidylinositol (PI) hydrolysis assays. Reduces serum parathyroid hormone levels in rats. Also potent CYP2D2 inhibitor (IC50 = 87 nM) and L-type calcium channel blocker. Orally bioavailable.

product keywords :

AMG073 calcium-sensing receptor CaSR allosteric agonists agonism calcimimetic CYP2D2 inhibitors inhibits L-type calcium channel blockers Sensipar AMG 073 Calcium-Sensing Receptor Cytochrome P450 Cav1.x Channels 6170,

extended description :

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

chemical name text :

N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine hydrochloride

formula :

C22H22F3N.HCl

formula text :

C22H22F3N.HCl

cas num :

364782-34-3

USD :

120

USD 2025 :

122 USD

product details :

Allosteric Calcium-sensing receptor (CaSR) agonist; also CYP2D2 inhibitor and Ca2+ channel blocker; orally bioavailable

alt names :

AMG 073

more info or order :

Tocris Bioscience product webpage