AMG 18 hydrochloride | Tocris Bioscience 6166 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AMG 18 hydrochloride

catalog :

6166

quantity :

5 mg

price :

260 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Xu Y, Melo Cardenas J, Zhang Y, Gau I, Wei J, Montauti E, et al. The E3 ligase Hrd1 stabilizes Tregs by antagonizing inflammatory cytokine-induced ER stress response. JCI Insight. 2019;4: pubmed publisher

product information

brand :

Tocris

master code :

6166

SKU :

6166/5

product name :

AMG 18 hydrochloride

description :

Potent and selective IRE1 inhibitor

target :

IRE1 Inhibitors

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

637.58

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective IRE1 inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1 , respectively). Exhibits selectivity for IRE1 in a panel of over 100 other kinases.

catalog number base :

6166

product keywords :

AMG18 HCl Potent IRE1alpha inhibitors inhibits selective IRE1 IRE endonuclease unfolded protein response inositol requiring enzyme 1 IRE1 6166,

extended description :

Potent and selective IRE1 inhibitor

chemical name text :

2-Chloro-N-[6-methyl-5-[[3-[2-[(3S)-3-piperidinylamino]-4-pyrimidinyl]-2-pyridinyl]oxy]-1-naphthalenyl]benzenesulfonamide hydrochloride

formula :

C 31 H 29 ClN 6 O 3 S.HCl

formula text :

C31H29ClN6O3S.HCl

cas num :

2250019-92-0

2020 USD :

247

2021 USD :

260 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage