SEA 0400 | Tocris Bioscience 6164/10 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SEA 0400

catalog :

6164/10

quantity :

10 mg (also 50 mg)

price :

232 USD

citations: 3

Reference
Neubert P, Homann A, Wendelborn D, Bär A, Krampert L, Trum M, et al. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020;18:e3000722 pubmed publisher
MacDougall M, Clarke R, Merrill B. Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency. Cell Stem Cell. 2019;: pubmed publisher
Hu H, Wang S, Wang Y, Liu Y, Feng X, Shen Y, et al. Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol. 2019;176:2691-2707 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6164

SKU :

6164/10

product name :

SEA 0400

description :

Potent Na+/Ca2+ exchanger (NCX) inhibitor

target :

Na+/Ca2+ Exchanger Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

371.38

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.

product keywords :

SEA0400 Inhibitors Inhibits NCX Na+/Ca2+ exchanger cardioprotectant Na+/Ca2+ Exchanger 6164,

extended description :

Potent Na+/Ca2+ exchanger (NCX) inhibitor

chemical name text :

2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine

formula :

C21H19F2NO3

formula text :

C21H19F2NO3

cas num :

223104-29-8

USD :

229

USD 2025 :

232 USD

product details :

Potent Na+/Ca2+ exchanger (NCX) inhibitor