Ailanthone | Tocris Bioscience 6161 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ailanthone

catalog :

6161

quantity :

5 mg

price :

119 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6161

SKU :

6161/5

product name :

Ailanthone

description :

Potent inhibitor of androgen receptor (AR)

target :

Androgen Receptor Antagonists

category :

Small Molecules

unit size :

5 mg

purity :

98%

observed molecular weight :

376.4

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent androgen receptor (AR) inhibitor (IC50 = 69 nM). Disrupts the AR-chaperone complex by binding p23 and blocking AR interaction with HSP90 causing UPS degradation of AR. Inhibits Huh7 cancer cell growth via G0/G1 cell cycle arrest and apoptosis in vitro and in vivo . Inhibits growth and metastasis of certain prostate cancer cell lines. Orally bioavailable.

catalog number base :

6161

product keywords :

Inhibitors Inhibits AR Androgen Receptor p23 HSP90 Ubiquitin Protease System UPS apoptosis prostate cancer Huh7 CRPC castration-resistant prostate cancer Androgen Receptor 6161,

extended description :

Potent inhibitor of androgen receptor (AR)

chemical name text :

(1 ,11 ,12 )-11,20-Epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione

formula :

C 20 H 24 O 7

formula text :

C20H24O7

cas num :

981-15-7

2020 USD :

119

2021 USD :

119 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage