4,9-Anhydrotetrodotoxin | Tocris Bioscience 6159/100U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

4,9-Anhydrotetrodotoxin

catalog :

6159/100U

quantity :

100 ug

price :

292 USD

citations: 4

Reference
Espino C, Lewis C, Ortiz S, Dalal M, Garlapalli S, Wells K, et al. NaV1.1 is essential for proprioceptive signaling and motor behaviors. elife. 2022;11: pubmed publisher
Mohammed Z, Kaloyanova K, Nassar M. An unbiased and efficient assessment of excitability of sensory neurons for analgesic drug discovery. Pain. 2020;161:1100-1108 pubmed publisher
Vysokov N, McMahon S, Raouf R. The role of NaV channels in synaptic transmission after axotomy in a microfluidic culture platform. Sci Rep. 2019;9:12915 pubmed publisher
Griffith T, Docter T, Lumpkin E. Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci. 2019;39:7086-7101 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6159

SKU :

6159/100U

product name :

4,9-Anhydrotetrodotoxin

description :

Potent and selective Nav1.6 channel blocker

target :

Voltage-gated Sodium Channel Blockers

unit size :

100 ug

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

301.25

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

4,9-Anhydrotetrodotoxin is a potent and selective Nav1.6 channel blocker (IC50 values are 7.8, 341, 988, 1260, 1270, 78500 and 30000 nM for Nav1.6, Nav1.3, Nav1.4, Nav1.2, Nav1.7, Nav1.5 and Nav1.8). Derivative of tetrodotoxin (Cat. No. 1078).

product keywords :

Na+ channel blockers sodium Nav 1.6 channels voltage-gated voltage-dependent potent selective ttx 4,9-anhydro-TTX Voltage-gated Sodium Channels 6159,

extended description :

Potent and selective Nav1.6 channel blocker

chemical name text :

(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol

formula :

C11H15N3O7

formula text :

C11H15N3O7

cas num :

13072-89-4

USD :

283

USD 2025 :

292 USD

product details :

Potent and selective Nav1.6 channel blocker

alt names :

4,9-anhydro-TTX