VH 298 | Tocris Bioscience 6156 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

VH 298

catalog :

6156

quantity :

10 mg (also 50 mg)

price :

244 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Qiu S, Jia Y, Sun Y, Han P, Xu J, Wen G, et al. Von Hippel-Lindau (VHL) Protein Antagonist VH298 Improves Wound Healing in Streptozotocin-Induced Hyperglycaemic Rats by Activating Hypoxia-Inducible Factor- (HIF-) 1 Signalling. J Diabetes Res. 2019;2019:1897174 pubmed publisher
Price C, GILL S, Ho Z, Davidson S, Merkel E, McFarland J, et al. Genome-Wide Interrogation of Human Cancers Identifies EGLN1 Dependency in Clear Cell Ovarian Cancers. Cancer Res. 2019;79:2564-2579 pubmed publisher

product information

brand :

Tocris

master code :

6156

SKU :

6156/10

product name :

VH 298

description :

High-affinity inhibitor of VHL

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

523.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High-affinity inhibitor of E3 ubiquitin ligase VHL (Kd = 80-90 nM). Blocks interaction between VHL and HIF- downstream of HIF- hydroxylation, initiating hypoxic response. Results in time- and concentration-dependent accumulation of hydroxylated HIF- , and upregulates mRNA and protein levels of HIF target genes, with similar transcriptional profile to hypoxia. Cell permeable. . Negative control cis VH 298 also available.

catalog number base :

6156

product keywords :

Inhibitors Inhibition VH298 VHL HIF-alpha HIF-a HIF- cisVH298 von Hippel-Lindau protein E3 ubiquitin ligase VH298 Hypoxia Inducible Factors Ubiquitin E3 Ligases 6156, E3 Ligase

extended description :

High-affinity inhibitor of VHL

chemical name text :

(2S,4R)-1-((S)-2-(1-cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

formula :

C 27 H 33 N 5 O 4 S

formula text :

C27H33N5O4S

cas num :

2097381-85-4

2020 USD :

234

2021 USD :

244 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage