JQEZ5 | Tocris Bioscience 6153 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JQEZ5

catalog :

6153

quantity :

10 mg (also 50 mg)

price :

169 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

6153

SKU :

6153/10

product name :

JQEZ5

description :

Potent and selective SAM-competitive EZH2 inhibitor

target :

EZH2 Inhibitor

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

542.69

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective SAM-competitive EZH2 lysine methyltransferase inhibitor (IC50 = 11 nM). Selectively binds EZH2 over a panel of 22 methyltransferases. Reduces global level of the PRC2-associated mark H3K27me3 in K562 cells. Suppresses cell growth in CML cells. Inhibits colony formation of primary human CD34+ CML stem/ progenitor cells. Antitumor effects in vivo .

catalog number base :

6153

product keywords :

potent selective EZH2 histone methyltransferase inhibitors inhibits PRC2 polycomb repressive complex 2 CML EZH2 Lysine Methyltransferases 6153, EZH 2, ENX 1, ENX1, KMT6, KMT 6

extended description :

Potent and selective SAM-competitive EZH2 inhibitor

chemical name text :

N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide

formula :

C 30 H 38 N 8 O 2

formula text :

C30H38N8O2

cas num :

1913252-04-6

2020 USD :

169

2021 USD :

169 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage