AP 1903 | Tocris Bioscience 6130/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AP 1903

catalog :

6130/5

quantity :

5 mg

price :

388 USD

more info or order :

Tocris Bioscience product webpage

image

image 1 :

Cat.No. 6130 - AP 1903 C78H98N4O20 CAS No. 195514-63-7

product information

brand :

Tocris

master code :

6130

SKU :

6130/5

rank :

0.06

product name :

AP 1903

description :

Chemical inducer of protein dimerization; active in vivo

target :

Protein Dimerizers

category :

Small Molecules

sizes available :

5 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AP 1903 is a chemical protein dimerizer for use in FKBP fusion protein systems. Induces apoptosis in cells expressing a fusion protein consisting of FKBPF36V and intracellular domain of Fas receptor with high potency (EC50 = 0.1 nM). Exhibits 50-fold selectivity for FKBPF36V-Fas fusion protein over wild-type FKBP. Also induces apoptosis in cells expressing Cas9-FK506 fusion proteins, in inducible caspase 9 (iCas9) suicide gene system. Active in vivo .

extended description :

Chemical inducer of protein dimerization; active in vivo

chemical name text :

2,2 -[1,2-Ethanediylbis[imino(2-oxo-2,1-ethanediyl)oxy-3,1-phenylene[(1R)-3-(3,4-dimethoxyphenyl)propylidene]]] bis[(2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate]

formula :

C 78 H 98 N 4 O 20

formula text :

C78H98N4O20

cas num :

195514-63-7

USD :

388 USD

product details :

Chemical inducer of protein dimerization; active in vivo

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage