(R)-2-Hydroxyglutaric acid disodium salt | Tocris Bioscience 6124 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-2-Hydroxyglutaric acid disodium salt

catalog :

6124

quantity :

50 mg

price :

115 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher

product information

brand :

Tocris

master code :

6124

SKU :

6124/50

product name :

(R)-2-Hydroxyglutaric acid disodium salt

description :

KDM4A inhibitor; also NF- B activator

target :

NFkB/IkB Activators

category :

Small Molecules

unit size :

50 mg

observed molecular weight :

192.08

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF- B in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).

catalog number base :

6124

product keywords :

2HG D-2HG oncometabolite mutant isocitrate dehydrogenase 1 2 IDH1 IDH2 NF-KB NF-kappaB NF- B activators activates mTOR mammalian Target of Rapamycin KDM4A lysine demethylases inhibitors inhibits FTO mRNA N6-methyladenine demethylase RNA D-alpha-hydroxyglutaric acid disodium salt Histone Demethylases NF-kB/IkB Isocitrate dehydrogenase 1 (IDH1) Other Oxygenases/Oxidases 6124,

extended description :

KDM4A inhibitor; also NF- B activator

chemical name text :

(R)-2-Hydroxypentanedioic acid disodium salt

formula :

C 5 H 6 Na 2 O 5

formula text :

C5H6Na2O5

cas num :

103404-90-6

2020 USD :

110

2021 USD :

115 USD

alt names :

D- -hydroxyglutaric acid disodium salt

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage