(R)-2-Hydroxyglutaric acid disodium salt | Tocris Bioscience 6124/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

(R)-2-Hydroxyglutaric acid disodium salt

catalog :

6124/50

quantity :

50 mg

price :

134 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher

product information

brand :

Tocris

master code :

6124

SKU :

6124/50

rank :

0.0007

product name :

(R)-2-Hydroxyglutaric acid disodium salt

description :

KDM4A inhibitor; also NF- B activator

target :

NFkB/IkB Activators

category :

Small Molecules

sizes available :

50 mg

url print :

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details of functionality :

( R )-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF- B in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).

extended description :

KDM4A inhibitor; also NF- B activator

chemical name text :

(R)-2-Hydroxypentanedioic acid disodium salt

formula :

C 5 H 6 Na 2 O 5

formula text :

C5H6Na2O5

cas num :

103404-90-6

USD :

134 USD

product details :

KDM4A inhibitor; also NF- B activator

alt names :

D- -hydroxyglutaric acid disodium salt

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage