PF 06273340 | Tocris Bioscience 6115/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 06273340

catalog :

6115/10

quantity :

10 mg

price :

234 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Olmez I, Zhang Y, Manigat L, Benamar M, Brenneman B, Nakano I, et al. Combined c-Met/Trk Inhibition Overcomes Resistance to CDK4/6 Inhibitors in Glioblastoma. Cancer Res. 2018;78:4360-4369 pubmed publisher

image

image 1 :

Cat.No. 6115 - PF 06273340 C23H22ClN7O3 CAS No. 1402438-74-7

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

6115

SKU :

6115/10

product name :

PF 06273340

description :

Potent and selective pan-Trk inhibitor; peripherally restricted

target :

Trk Receptor Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

479.93

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PF 06273340 is a potent and selective pan-Trk inhibitor (IC50 values are 1, 2 and 6 nM for Trk C, B and A, respectively). Selective for Trk over a panel of ion channels, receptors and other enzymes. Peripherally restricted. Exhibits efficacy in a rodent model of inflammatory pain. Orally bioavailable.

product keywords :

PF06273340 Trk A B C tropomyosin-related kinase receptors neurotrophins inhibitors inhibits peripherally restricted potent selective Trk Receptors 6115,

extended description :

Potent and selective pan-Trk inhibitor; peripherally restricted

chemical name text :

N-[5-[[2-Amino-7-(2-hydroxy-1,1-dimethylethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]carbonyl]-3-pyridinyl]-5-chloro-2-pyridineacetamide

formula :

C23H22ClN7O3

formula text :

C23H22ClN7O3

cas num :

1402438-74-7

USD :

231

USD 2025 :

234 USD

product details :

Potent and selective pan-Trk inhibitor; peripherally restricted

more info or order :

Tocris Bioscience product webpage