PF 06409577 | Tocris Bioscience 6114 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 06409577

catalog :

6114

quantity :

10 mg (also 50 mg)

price :

179 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Smith H, Hirukawa A, Sanguin Gendreau V, Nandi I, Dufour C, Zuo D, et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nat Commun. 2019;10:2901 pubmed publisher

product information

brand :

Tocris

master code :

6114

SKU :

6114/10

product name :

PF 06409577

description :

Potent and selective allosteric activator of AMPK

target :

AMPK Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

341.79

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective allosteric activator of AMPK (EC50 values are 7 and 40000 nM for AMPK 1 1 1 and AMPK 1 2 1, respectively). Exhibits minimal off-target effects on a panel of receptors, ion channels, PDEs and kinases. Improves kidney function and reduces proteinuria in a preclinical model of diabetic nephropathy. Orally bioavailable.

catalog number base :

6114

product keywords :

PF06409577 AMP-activated protein kinase AMPK activators activates diabetic nephropathy potent selective allosteric orally bioavailable 1 1 1 AMPK Enzyme Substrates/ Activators 6114,

extended description :

Potent and selective allosteric activator of AMPK

chemical name text :

6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid

formula :

C 19 H 16 ClNO 3

formula text :

C19H16ClNO3

cas num :

1467057-23-3

2020 USD :

175

2021 USD :

179 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage